IR spectroscopy has been proven to characterize cellular abnormalities related to a variety of cancers from different organs.IR (micro-)spectroscopy offers a number of advantages to analyse human tissues over existed «golden standard», a histopathological method, in vitro. IR spectroscopy is used on the unstained tissues, it has a high sensitivity to provide qualitative and quantitative information of proteins, nucleic acids, lipids and other biomolecules on the molecular level, suitable for differentiation between healthy and cancerous tissues. IR spectral diagnosis offers development of biomarker(s), pattern recognition by means of characterization of nucleic acids and proteins in the tissue, alone and in combination.
To introduce IR (micro-)spectroscopy as a complimentary diagnostic tool in oncology for in vitro and in vivo applications in the clinic and in pharma, possibly as a guided method for personalized medical treatment. IR (micro-)spectroscopy for in vitro diagnosis aims to introduce a method, suitable for understanding response to therapy in correlation with spectrally determined molecular alterations in the tissue. In vivo diagnosis and follow-up of the treated patients aims to provide a possibility to reach any anatomical location by specially designed fiberoptics for IR spectroscopy based instrumentation for spectral acquision and further molecular analysis, thus supporting clinical diagnosis and follow-up of therapeutic effect directly on the patients.
- Fiber optic IR spectroscopy, FTIR microspectroscopy
- In vitro cancer diagnostics by FTIR microspectroscopy towards in vivo cancer diagnostics by
R & D of fiberoptics for IR spectroscopy based instrumentation.